产品说明：

SU 5402是一种有效的选择性成纤维细胞生长因子受体（FGFR）和血管内皮生长因子受体（VEGFR）抑制剂。据报道，它具有抗肿瘤特性，减弱整合素β4诱导的神经干细胞分化，并抑制胚胎左右决定。

SU 5402 is a potent and selective fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) inhibitor. It is reported to exhibit antitumor properties, attenuates the integrin Beta4-induced differentiation of neural stem cells, and inhibits embryonic left-right determination.

产品信息：

应用:   FA

同义词:  A SU5402, SU-5402

配方: Crystalline solid

化学名称: 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

分子式: C₁₇H₁₆N₂O₃

分子量:296.3

CAS号：215543-92-3

纯度：≥98%

储存条件：产品应保持在-20°C。

参考：

Grand, E. K., Chase, A. J., Heath, C., Rahemtulla, A., & Cross, N. C. P. (2004). Targeting FGFR3 in multiple myeloma: inhibition of t (4; 14)-positive cells by SU5402 and PD173074. Leukemia, 18(5), 962.

Gudernova, I., Vesela, I., Balek, L., Buchtova, M., Dosedelova, H., Kunova, M., ... & Krejci, P. (2015). Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes. Human molecular genetics, 25(1), 9-23.

Tomescot, A., Leschik, J., Bellamy, V., Dubois, G., Messas, E., Bruneval, P., ... & Menasché, P. (2007). Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats. Stem Cells, 25(9), 2200-2205.